Drug interactions
Fluticasone furoate + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Major
Fluticasone furoate and Ombitasvir / paritaprevir / ritonavir and dasabuvir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir in this regimen strongly inhibits CYP3A4 and can greatly increase fluticasone exposure. This has caused systemic corticosteroid effects including Cushing syndrome and adrenal suppression with related inhaled steroids.
What this interaction means in plain words
Fluticasone furoate and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ritonavir-mediated CYP3A4 inhibition reduces fluticasone clearance, increasing systemic exposure.
What to do
Avoid the combination, especially for long-term use, and switch to a corticosteroid less dependent on CYP3A4 such as beclomethasone. If it must be used, monitor for adrenal suppression and Cushingoid effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Frequently asked questions
Can I take Fluticasone furoate with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as major. Fluticasone furoate and Ombitasvir / paritaprevir / ritonavir and dasabuvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir in this regimen strongly inhibits CYP3A4 and can greatly increase fluticasone exposure. This has caused systemic corticosteroid effects including Cushing syndrome and adrenal suppression with related inhaled steroids.
How serious is the interaction between Fluticasone furoate and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination, especially for long-term use, and switch to a corticosteroid less dependent on CYP3A4 such as beclomethasone. If it must be used, monitor for adrenal suppression and Cushingoid effects.
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