Drug interactions
Fluticasone furoate + Phenobarbital
Severity: Minor
Fluticasone furoate and Phenobarbital: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital induces CYP3A4 and may lower fluticasone furoate exposure. With inhaled or intranasal dosing the effect is usually minor, but disease control could be reduced.
What this interaction means in plain words
Fluticasone furoate and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenobarbital induces hepatic and intestinal CYP3A4, increasing fluticasone clearance.
What to do
Monitor symptom control and adjust the corticosteroid dose if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Fluticasone furoate and Phenobarbital, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Frequently asked questions
Can I take Fluticasone furoate with Phenobarbital?
MediHelp rates the interaction as minor. Fluticasone furoate and Phenobarbital have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenobarbital induces CYP3A4 and may lower fluticasone furoate exposure. With inhaled or intranasal dosing the effect is usually minor, but disease control could be reduced.
How serious is the interaction between Fluticasone furoate and Phenobarbital?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and adjust the corticosteroid dose if response is inadequate.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
