Drug interactions
Fluticasone furoate + Phenytoin
Severity: Minor
Fluticasone furoate and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin induces CYP3A4 and may lower fluticasone furoate exposure. This could reduce control of asthma or allergic rhinitis symptoms.
What this interaction means in plain words
Fluticasone furoate and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 by phenytoin increases metabolism of fluticasone furoate.
What to do
Monitor symptom control and consider dose adjustment or an alternative therapy if response is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Fluticasone furoate with Phenytoin?
MediHelp rates the interaction as minor. Fluticasone furoate and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin induces CYP3A4 and may lower fluticasone furoate exposure. This could reduce control of asthma or allergic rhinitis symptoms.
How serious is the interaction between Fluticasone furoate and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor symptom control and consider dose adjustment or an alternative therapy if response is inadequate.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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