Drug interactions
Fluticasone furoate + Saquinavir
Severity: Major
Fluticasone furoate and Saquinavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually given with ritonavir, inhibits CYP3A4 and can raise systemic fluticasone furoate levels. This increases the risk of Cushingoid effects and adrenal suppression.
What this interaction means in plain words
Fluticasone furoate and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Saquinavir/ritonavir inhibits CYP3A4, reducing fluticasone clearance.
What to do
Prefer beclomethasone or another alternative for long-term therapy; if co-used, monitor for adrenal suppression and corticosteroid excess.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Frequently asked questions
Can I take Fluticasone furoate with Saquinavir?
MediHelp rates the interaction as major. Fluticasone furoate and Saquinavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Saquinavir, usually given with ritonavir, inhibits CYP3A4 and can raise systemic fluticasone furoate levels. This increases the risk of Cushingoid effects and adrenal suppression.
How serious is the interaction between Fluticasone furoate and Saquinavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer beclomethasone or another alternative for long-term therapy; if co-used, monitor for adrenal suppression and corticosteroid excess.
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