Drug interactions
Fluticasone inhaled + Phenytoin
Severity: Minor
Fluticasone inhaled and Phenytoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin may reduce systemic fluticasone exposure. With inhaled dosing, the effect on local asthma control is likely small.
What this interaction means in plain words
Fluticasone inhaled and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Phenytoin induces CYP3A4, increasing fluticasone clearance.
What to do
Monitor asthma or respiratory control and adjust the inhaled corticosteroid dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Fluticasone inhaled with Phenytoin?
MediHelp rates the interaction as minor. Fluticasone inhaled and Phenytoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenytoin may reduce systemic fluticasone exposure. With inhaled dosing, the effect on local asthma control is likely small.
How serious is the interaction between Fluticasone inhaled and Phenytoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or respiratory control and adjust the inhaled corticosteroid dose if control worsens.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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