Drug interactions
Fo-ti + Hydrochlorothiazide-olmesartan
Severity: Minor
Fo-ti and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fo-ti (Polygonum multiflorum) contains anthraquinones with laxative activity that may cause potassium loss. With hydrochlorothiazide this could add to hypokalemia, though the evidence is largely theoretical.
What this interaction means in plain words
Fo-ti and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive potassium loss from anthraquinone laxative effect and thiazide kaliuresis.
What to do
Advise against prolonged use of fo-ti, which also carries a hepatotoxicity concern, and check serum potassium if diarrhea or long-term use occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Fo-ti with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Fo-ti and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fo-ti (Polygonum multiflorum) contains anthraquinones with laxative activity that may cause potassium loss. With hydrochlorothiazide this could add to hypokalemia, though the evidence is largely theoretical.
How serious is the interaction between Fo-ti and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against prolonged use of fo-ti, which also carries a hepatotoxicity concern, and check serum potassium if diarrhea or long-term use occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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