Drug interactions
Formoterol + Lofepramine
Severity: Moderate
Formoterol and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can prolong the QT interval and potentiate the cardiovascular effects of beta-2 agonists. Combining lofepramine with formoterol may lead to tachycardia, palpitations and arrhythmia.
What this interaction means in plain words
Formoterol and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, and tricyclic-related noradrenergic reuptake inhibition that enhances sympathomimetic cardiovascular effects.
What to do
Monitor heart rate, rhythm and ECG when starting or changing doses, and check potassium. Consider alternative therapy in patients with arrhythmia or QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Lofepramine?
MediHelp rates the interaction as moderate. Formoterol and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can prolong the QT interval and potentiate the cardiovascular effects of beta-2 agonists. Combining lofepramine with formoterol may lead to tachycardia, palpitations and arrhythmia.
How serious is the interaction between Formoterol and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and ECG when starting or changing doses, and check potassium. Consider alternative therapy in patients with arrhythmia or QT risk.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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