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Drug interactions

Formoterol + Metaproterenol

Severity: Moderate

Formoterol and Metaproterenol: moderate interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Both are beta-agonists, so combined use adds to hypokalemia, tachycardia, tremor and blood pressure effects. This may precipitate arrhythmias in patients with cardiovascular disease.

What this interaction means in plain words

Formoterol and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Evidence level: Moderate

Why it happens

Additive beta adrenergic stimulation.

What to do

Avoid regular concurrent use of two beta-agonists and monitor heart rate and potassium if both are necessary.

What to ask your pharmacist

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Formoterol with Metaproterenol?

MediHelp rates the interaction as moderate. Formoterol and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are beta-agonists, so combined use adds to hypokalemia, tachycardia, tremor and blood pressure effects. This may precipitate arrhythmias in patients with cardiovascular disease.

How serious is the interaction between Formoterol and Metaproterenol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular concurrent use of two beta-agonists and monitor heart rate and potassium if both are necessary.

What other medicines interact with Formoterol?

MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.

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