Drug interactions
Formoterol + Olodaterol inhaled
Severity: Major
Formoterol and Olodaterol inhaled: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are long-acting beta-2 agonists, so combining them duplicates therapy and increases the risk of tachycardia, hypertension, tremor and hypokalemia. There is no added bronchodilator benefit that outweighs this risk.
What this interaction means in plain words
Formoterol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive beta-2 adrenergic receptor stimulation.
What to do
Avoid concurrent use of two long-acting beta-agonists and use only one LABA at a time.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Olodaterol inhaled?
MediHelp rates the interaction as major. Formoterol and Olodaterol inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both are long-acting beta-2 agonists, so combining them duplicates therapy and increases the risk of tachycardia, hypertension, tremor and hypokalemia. There is no added bronchodilator benefit that outweighs this risk.
How serious is the interaction between Formoterol and Olodaterol inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two long-acting beta-agonists and use only one LABA at a time.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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