Drug interactions
Formoterol + Phenylephrine po
Severity: Moderate
Formoterol and Phenylephrine po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral phenylephrine is a sympathomimetic that can raise blood pressure, and formoterol can raise heart rate and cause palpitations. Used together they may add to cardiovascular stimulation, which matters in patients with hypertension or heart disease.
What this interaction means in plain words
Formoterol and Phenylephrine po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation from alpha-1 agonism by phenylephrine and beta-2 agonism by formoterol.
What to do
Monitor blood pressure and heart rate, and avoid oral decongestants in patients with uncontrolled hypertension or arrhythmia. Consider non-sympathomimetic alternatives for nasal congestion.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Phenylephrine po?
MediHelp rates the interaction as moderate. Formoterol and Phenylephrine po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral phenylephrine is a sympathomimetic that can raise blood pressure, and formoterol can raise heart rate and cause palpitations. Used together they may add to cardiovascular stimulation, which matters in patients with hypertension or heart disease.
How serious is the interaction between Formoterol and Phenylephrine po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and avoid oral decongestants in patients with uncontrolled hypertension or arrhythmia. Consider non-sympathomimetic alternatives for nasal congestion.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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