Drug interactions
Formoterol + Protriptyline
Severity: Moderate
Formoterol and Protriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant that can prolong the QT interval and potentiate adrenergic cardiovascular effects. With formoterol this may cause tachycardia, palpitations and arrhythmia.
What this interaction means in plain words
Formoterol and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, and tricyclic blockade of noradrenaline reuptake that enhances sympathomimetic effects.
What to do
Monitor heart rate, rhythm and ECG, particularly at initiation or dose change, and check potassium. Consider an alternative in patients with arrhythmia or QT risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Protriptyline?
MediHelp rates the interaction as moderate. Formoterol and Protriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant that can prolong the QT interval and potentiate adrenergic cardiovascular effects. With formoterol this may cause tachycardia, palpitations and arrhythmia.
How serious is the interaction between Formoterol and Protriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, rhythm and ECG, particularly at initiation or dose change, and check potassium. Consider an alternative in patients with arrhythmia or QT risk.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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