Drug interactions
Formoterol + Vilanterol / fluticasone furoate inhaled
Severity: Major
Formoterol and Vilanterol / fluticasone furoate inhaled: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol and vilanterol are both long-acting beta-2 agonists, so combining them duplicates therapy and raises the risk of adverse cardiovascular effects. Tachycardia, palpitations, QT prolongation, hypokalemia and tremor may occur.
What this interaction means in plain words
Formoterol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate beta-2 adrenergic agonism producing additive cardiovascular and hypokalemic effects.
What to do
Avoid concurrent use of two long-acting beta agonists and select a single regimen. Monitor heart rate and potassium if overlap has occurred.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as major. Formoterol and Vilanterol / fluticasone furoate inhaled can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Formoterol and vilanterol are both long-acting beta-2 agonists, so combining them duplicates therapy and raises the risk of adverse cardiovascular effects. Tachycardia, palpitations, QT prolongation, hypokalemia and tremor may occur.
How serious is the interaction between Formoterol and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two long-acting beta agonists and select a single regimen. Monitor heart rate and potassium if overlap has occurred.
What other medicines interact with Formoterol?
MediHelp also lists interactions of Formoterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Formoterol page.
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