Drug interactions
Formoterol + Xylometazoline
Severity: Moderate
Formoterol and Xylometazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Formoterol is a long-acting beta-2 agonist that can increase heart rate and cause palpitations. Xylometazoline is a vasoconstrictor that may raise blood pressure when absorbed systemically. Combined use may add to cardiovascular stimulation, particularly in patients with heart disease.
What this interaction means in plain words
Formoterol and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Formoterol belongs to Respiratory; Xylometazoline belongs to Respiratory.
Why it happens
Additive sympathomimetic effects on the cardiovascular system.
What to do
Monitor heart rate and blood pressure in patients with cardiovascular disease who use both. Keep xylometazoline to short courses at labeled doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Other interactions of Formoterol
- Adagrasib + Formoterol Major
- Amiodarone + Formoterol Major
- Amisulpride + Formoterol Major
- Amitriptyline + Formoterol Major
- Amoxapine + Formoterol Major
- Arformoterol + Formoterol Major
Frequently asked questions
Can I take Formoterol with Xylometazoline?
MediHelp rates the interaction as moderate. Formoterol and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Formoterol is a long-acting beta-2 agonist that can increase heart rate and cause palpitations. Xylometazoline is a vasoconstrictor that may raise blood pressure when absorbed systemically. Combined use may add to cardiovascular stimulation, particularly in patients with heart disease.
How serious is the interaction between Formoterol and Xylometazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure in patients with cardiovascular disease who use both. Keep xylometazoline to short courses at labeled doses.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
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