Drug interactions
Fosamprenavir + Glibenclamide
Severity: Moderate
Fosamprenavir and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as fosamprenavir (via amprenavir) can induce insulin resistance and hyperglycemia, which may reduce the effect of glyburide.
What this interaction means in plain words
Fosamprenavir and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitor-associated insulin resistance and impaired glucose metabolism oppose the glucose-lowering effect of glyburide.
What to do
Monitor blood glucose and HbA1c after starting fosamprenavir and intensify the antidiabetic regimen if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Fosamprenavir with Glibenclamide?
MediHelp rates the interaction as moderate. Fosamprenavir and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as fosamprenavir (via amprenavir) can induce insulin resistance and hyperglycemia, which may reduce the effect of glyburide.
How serious is the interaction between Fosamprenavir and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting fosamprenavir and intensify the antidiabetic regimen if needed.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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