Drug interactions
Fosamprenavir + Griseofulvin
Severity: Moderate
Fosamprenavir and Griseofulvin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak inducer of CYP3A4 and may lower the plasma concentration of amprenavir, the active form of fosamprenavir. Reduced protease inhibitor exposure could weaken viral suppression and promote resistance.
What this interaction means in plain words
Fosamprenavir and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by griseofulvin increases amprenavir metabolism.
What to do
Monitor HIV viral load and consider antiretroviral drug level monitoring if available during co-therapy. Keep the griseofulvin course as short as possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Frequently asked questions
Can I take Fosamprenavir with Griseofulvin?
MediHelp rates the interaction as moderate. Fosamprenavir and Griseofulvin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin is a weak inducer of CYP3A4 and may lower the plasma concentration of amprenavir, the active form of fosamprenavir. Reduced protease inhibitor exposure could weaken viral suppression and promote resistance.
How serious is the interaction between Fosamprenavir and Griseofulvin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider antiretroviral drug level monitoring if available during co-therapy. Keep the griseofulvin course as short as possible.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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