Drug interactions
Fosamprenavir + Insulin aspart
Severity: Moderate
Fosamprenavir and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as amprenavir (the active form of fosamprenavir) have been associated with insulin resistance and hyperglycemia. Insulin needs may increase.
What this interaction means in plain words
Fosamprenavir and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors may reduce peripheral insulin sensitivity, antagonizing insulin.
What to do
Monitor glucose more frequently when fosamprenavir is started or stopped. Titrate the insulin dose to maintain glycemic targets.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart
Frequently asked questions
Can I take Fosamprenavir with Insulin aspart?
MediHelp rates the interaction as moderate. Fosamprenavir and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as amprenavir (the active form of fosamprenavir) have been associated with insulin resistance and hyperglycemia. Insulin needs may increase.
How serious is the interaction between Fosamprenavir and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose more frequently when fosamprenavir is started or stopped. Titrate the insulin dose to maintain glycemic targets.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
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