Drug interactions
Fosamprenavir + Insulin detemir
Severity: Moderate
Fosamprenavir and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir, a protease inhibitor prodrug of amprenavir, may cause insulin resistance and hyperglycemia, reducing insulin effect.
What this interaction means in plain words
Fosamprenavir and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors can impair peripheral glucose uptake and insulin sensitivity, antagonizing insulin.
What to do
Monitor blood glucose after starting fosamprenavir and increase the insulin detemir dose if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin detemir
Frequently asked questions
Can I take Fosamprenavir with Insulin detemir?
MediHelp rates the interaction as moderate. Fosamprenavir and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir, a protease inhibitor prodrug of amprenavir, may cause insulin resistance and hyperglycemia, reducing insulin effect.
How serious is the interaction between Fosamprenavir and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting fosamprenavir and increase the insulin detemir dose if hyperglycemia develops.
What other medicines interact with Insulin detemir?
MediHelp also lists interactions of Insulin detemir with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin detemir page.
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