Drug interactions
Fosamprenavir + Ketamine
Severity: Moderate
Fosamprenavir and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (amprenavir) is usually given with ritonavir, which inhibits CYP3A4, so ketamine levels are more likely to increase than decrease. This may prolong sedation and increase hemodynamic effects.
What this interaction means in plain words
Fosamprenavir and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Altered CYP3A4 metabolism of ketamine, predominantly inhibition by the boosted regimen.
What to do
Titrate ketamine to effect and monitor sedation and vital signs, anticipating possible prolonged recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Frequently asked questions
Can I take Fosamprenavir with Ketamine?
MediHelp rates the interaction as moderate. Fosamprenavir and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fosamprenavir (amprenavir) is usually given with ritonavir, which inhibits CYP3A4, so ketamine levels are more likely to increase than decrease. This may prolong sedation and increase hemodynamic effects.
How serious is the interaction between Fosamprenavir and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to effect and monitor sedation and vital signs, anticipating possible prolonged recovery.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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