Drug interactions
Fosamprenavir + Zaleplon
Severity: Minor
Fosamprenavir and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fosamprenavir (as amprenavir) inhibits CYP3A4 and may modestly raise zaleplon levels. Because zaleplon is metabolized mainly by aldehyde oxidase, the increase is expected to be small, but additional sedation is possible.
What this interaction means in plain words
Fosamprenavir and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Amprenavir inhibits CYP3A4, which handles a minor fraction of zaleplon metabolism.
What to do
Use the usual zaleplon dose and monitor for excessive drowsiness or next-day impairment, especially in older patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Frequently asked questions
Can I take Fosamprenavir with Zaleplon?
MediHelp rates the interaction as minor. Fosamprenavir and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fosamprenavir (as amprenavir) inhibits CYP3A4 and may modestly raise zaleplon levels. Because zaleplon is metabolized mainly by aldehyde oxidase, the increase is expected to be small, but additional sedation is possible.
How serious is the interaction between Fosamprenavir and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the usual zaleplon dose and monitor for excessive drowsiness or next-day impairment, especially in older patients.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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