Drug interactions
Gabapentin + Meprobamate
Severity: Moderate
Gabapentin and Meprobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents depress the CNS, and together they can cause marked drowsiness, impaired coordination and slowed breathing. The risk is higher in older adults, those with lung disease and those taking other sedatives.
What this interaction means in plain words
Gabapentin and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Use the lowest effective doses and titrate slowly. Monitor for oversedation and respiratory depression, and advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Meprobamate?
MediHelp rates the interaction as moderate. Gabapentin and Meprobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents depress the CNS, and together they can cause marked drowsiness, impaired coordination and slowed breathing. The risk is higher in older adults, those with lung disease and those taking other sedatives.
How serious is the interaction between Gabapentin and Meprobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and titrate slowly. Monitor for oversedation and respiratory depression, and advise against driving until the response is known.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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