Drug interactions
Gabapentin + Metoclopramide intranasal
Severity: Moderate
Gabapentin and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metoclopramide can cause drowsiness, extrapyramidal reactions and mood effects, and gabapentin can cause sedation and dizziness. Used together, they may increase CNS adverse effects, although the clinical significance is likely modest.
What this interaction means in plain words
Gabapentin and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive CNS adverse effects; no specific pharmacokinetic mechanism is established.
What to do
Monitor for sedation, dizziness and movement disorders. Consider an alternative antiemetic if CNS effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Gabapentin and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metoclopramide can cause drowsiness, extrapyramidal reactions and mood effects, and gabapentin can cause sedation and dizziness. Used together, they may increase CNS adverse effects, although the clinical significance is likely modest.
How serious is the interaction between Gabapentin and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and movement disorders. Consider an alternative antiemetic if CNS effects develop.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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