Drug interactions
Gabapentin + Nefazodone
Severity: Minor
Gabapentin and Nefazodone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause sedation and dizziness, and their combination may amplify drowsiness and psychomotor impairment. Serious respiratory depression is unlikely in healthy patients but may occur in those with risk factors.
What this interaction means in plain words
Gabapentin and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Titrate gabapentin slowly and monitor for excessive sedation and dizziness. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Nefazodone?
MediHelp rates the interaction as minor. Gabapentin and Nefazodone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause sedation and dizziness, and their combination may amplify drowsiness and psychomotor impairment. Serious respiratory depression is unlikely in healthy patients but may occur in those with risk factors.
How serious is the interaction between Gabapentin and Nefazodone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate gabapentin slowly and monitor for excessive sedation and dizziness. Counsel patients about driving and operating machinery.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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