Drug interactions
Gabapentin + Sufentanil sl
Severity: Major
Gabapentin and Sufentanil sl: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin and sublingual sufentanil both depress the central nervous system. Combined use raises the risk of profound sedation, respiratory depression and death.
What this interaction means in plain words
Gabapentin and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS and respiratory depression.
What to do
Use the lowest effective doses and monitor respiratory rate and sedation level closely. Counsel patients and caregivers to recognise oversedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Sufentanil sl?
MediHelp rates the interaction as major. Gabapentin and Sufentanil sl can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gabapentin and sublingual sufentanil both depress the central nervous system. Combined use raises the risk of profound sedation, respiratory depression and death.
How serious is the interaction between Gabapentin and Sufentanil sl?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor respiratory rate and sedation level closely. Counsel patients and caregivers to recognise oversedation.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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