Drug interactions
Gabapentin + Triazolam
Severity: Major
Gabapentin and Triazolam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a potent short-acting benzodiazepine, and gabapentin adds to its CNS depressant effects. The combination can cause deep sedation, impaired coordination and respiratory depression.
What this interaction means in plain words
Gabapentin and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS and respiratory depression.
What to do
Avoid the combination where possible, or use the lowest doses for the shortest time. Monitor for sedation and respiratory depression, especially in older adults.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gabapentin
Frequently asked questions
Can I take Gabapentin with Triazolam?
MediHelp rates the interaction as major. Gabapentin and Triazolam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Triazolam is a potent short-acting benzodiazepine, and gabapentin adds to its CNS depressant effects. The combination can cause deep sedation, impaired coordination and respiratory depression.
How serious is the interaction between Gabapentin and Triazolam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or use the lowest doses for the shortest time. Monitor for sedation and respiratory depression, especially in older adults.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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