Drug interactions
Ganciclovir + Ketorolac
Severity: Moderate
Ganciclovir and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated by active renal tubular secretion and competition may raise ganciclovir exposure. Ketorolac may also reduce renal function, further reducing ganciclovir clearance.
What this interaction means in plain words
Ganciclovir and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ganciclovir belongs to Anti Virals; Ketorolac belongs to Musculoskeletal.
Why it happens
Competition for renal organic anion transport plus NSAID-related reduction in renal function lowers ganciclovir clearance.
What to do
Monitor renal function and blood counts for ganciclovir toxicity and adjust the dose to creatinine clearance. Avoid prolonged ketorolac use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ganciclovir and Ketorolac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Ketorolac?
MediHelp rates the interaction as moderate. Ganciclovir and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are eliminated by active renal tubular secretion and competition may raise ganciclovir exposure. Ketorolac may also reduce renal function, further reducing ganciclovir clearance.
How serious is the interaction between Ganciclovir and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts for ganciclovir toxicity and adjust the dose to creatinine clearance. Avoid prolonged ketorolac use.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
