Drug interactions
Ganciclovir + Peramivir
Severity: Minor
Ganciclovir and Peramivir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peramivir is cleared almost entirely by the kidneys, and ganciclovir can impair renal function in some patients. Reduced kidney function may raise peramivir exposure. The practical effect is mostly a concern in patients with existing renal impairment.
What this interaction means in plain words
Ganciclovir and Peramivir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible reduction in renal clearance of peramivir through additive nephrotoxicity; no direct tubular competition is firmly established.
What to do
Monitor serum creatinine and estimated creatinine clearance, and adjust the peramivir dose according to labeling if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ganciclovir and Peramivir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Peramivir?
MediHelp rates the interaction as minor. Ganciclovir and Peramivir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peramivir is cleared almost entirely by the kidneys, and ganciclovir can impair renal function in some patients. Reduced kidney function may raise peramivir exposure. The practical effect is mostly a concern in patients with existing renal impairment.
How serious is the interaction between Ganciclovir and Peramivir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and estimated creatinine clearance, and adjust the peramivir dose according to labeling if renal function declines.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
