Drug interactions
Ganciclovir + Tenofovir df
Severity: Moderate
Ganciclovir and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are eliminated renally, and both can contribute to kidney injury. Combined use may increase tenofovir or ganciclovir exposure, particularly in patients with reduced renal function. This increases the risk of renal toxicity and of ganciclovir myelosuppression.
What this interaction means in plain words
Ganciclovir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion and additive nephrotoxic potential.
What to do
Monitor serum creatinine, phosphate and blood counts regularly, and adjust doses to creatinine clearance. Consider an alternative if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Tenofovir df?
MediHelp rates the interaction as moderate. Ganciclovir and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are eliminated renally, and both can contribute to kidney injury. Combined use may increase tenofovir or ganciclovir exposure, particularly in patients with reduced renal function. This increases the risk of renal toxicity and of ganciclovir myelosuppression.
How serious is the interaction between Ganciclovir and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and blood counts regularly, and adjust doses to creatinine clearance. Consider an alternative if renal function deteriorates.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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