Drug interactions
Ganciclovir + Tenofovir disoproxil
Severity: Moderate
Ganciclovir and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are cleared by the kidney, including tubular secretion, so competition may modestly increase concentrations of either. Impaired renal function from other causes would amplify this effect.
What this interaction means in plain words
Ganciclovir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for active renal tubular secretion and dependence on renal function for elimination.
What to do
Monitor renal function and blood counts, and dose-adjust ganciclovir and tenofovir for creatinine clearance. Watch for signs of tenofovir tubular toxicity or ganciclovir myelosuppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ganciclovir
Frequently asked questions
Can I take Ganciclovir with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Ganciclovir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are cleared by the kidney, including tubular secretion, so competition may modestly increase concentrations of either. Impaired renal function from other causes would amplify this effect.
How serious is the interaction between Ganciclovir and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and blood counts, and dose-adjust ganciclovir and tenofovir for creatinine clearance. Watch for signs of tenofovir tubular toxicity or ganciclovir myelosuppression.
What other medicines interact with Ganciclovir?
MediHelp also lists interactions of Ganciclovir with, for example, Bacitracin, Cilastatin-imipenem, Didanosine. The full list is on the Ganciclovir page.
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