Drug interactions
Gemtuzumab + Salbutamol
Severity: Moderate
Gemtuzumab and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemtuzumab ozogamicin has been associated with QT prolongation, and beta-agonists such as salbutamol may add to this effect, especially when potassium falls. The risk is mainly relevant in patients with additional QT risk factors.
What this interaction means in plain words
Gemtuzumab and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with beta-agonist hypokalemia as a possible contributor.
What to do
Obtain baseline and periodic ECG and correct potassium and magnesium abnormalities in patients receiving both drugs. Limit salbutamol to the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Frequently asked questions
Can I take Gemtuzumab with Salbutamol?
MediHelp rates the interaction as moderate. Gemtuzumab and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemtuzumab ozogamicin has been associated with QT prolongation, and beta-agonists such as salbutamol may add to this effect, especially when potassium falls. The risk is mainly relevant in patients with additional QT risk factors.
How serious is the interaction between Gemtuzumab and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and periodic ECG and correct potassium and magnesium abnormalities in patients receiving both drugs. Limit salbutamol to the lowest effective dose.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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