Drug interactions
Ginger + Phenindione
Severity: Moderate
Ginger and Phenindione: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ginger may add to the bleeding tendency of the vitamin K antagonist phenindione, although clinical studies with warfarin have not shown consistent changes in INR. The effect is mainly theoretical but anticoagulant bleeding can be serious.
What this interaction means in plain words
Ginger and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic effect: vitamin K antagonism plus possible antiplatelet activity of ginger.
What to do
Discourage ginger supplements during phenindione therapy. If used, monitor INR more frequently and watch for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ginger
- Aceclofenac + Ginger Moderate
- Acemetacin + Ginger Moderate
- Aescin + Ginger Moderate
- Aspirin / citric acid / sodium bicarbonate + Ginger Moderate
- Aspirin rectal + Ginger Moderate
- Aspirin + Ginger Moderate
Frequently asked questions
Can I take Ginger with Phenindione?
MediHelp rates the interaction as moderate. Ginger and Phenindione can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ginger may add to the bleeding tendency of the vitamin K antagonist phenindione, although clinical studies with warfarin have not shown consistent changes in INR. The effect is mainly theoretical but anticoagulant bleeding can be serious.
How serious is the interaction between Ginger and Phenindione?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Discourage ginger supplements during phenindione therapy. If used, monitor INR more frequently and watch for bleeding.
What other medicines interact with Ginger?
MediHelp also lists interactions of Ginger with, for example, Aceclofenac, Acemetacin, Aescin. The full list is on the Ginger page.
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