Drug interactions
Glecaprevir / pibrentasvir + Glibenclamide
Severity: Moderate
Glecaprevir / pibrentasvir and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-gp, BCRP and OATP1B1/1B3, which may increase glyburide exposure and the risk of hypoglycemia. Glyburide is itself an OATP substrate and inhibitor, so reciprocal effects are possible but less important. Improved glycemic control after hepatitis C cure may also lower glucose requirements.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of intestinal and hepatic transporters (P-gp, BCRP, OATP) by glecaprevir/pibrentasvir raises glyburide concentrations.
What to do
Monitor blood glucose during and after hepatitis C therapy and reduce the glyburide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Glibenclamide?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit P-gp, BCRP and OATP1B1/1B3, which may increase glyburide exposure and the risk of hypoglycemia. Glyburide is itself an OATP substrate and inhibitor, so reciprocal effects are possible but less important. Improved glycemic control after hepatitis C cure may also lower glucose requirements.
How serious is the interaction between Glecaprevir / pibrentasvir and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after hepatitis C therapy and reduce the glyburide dose if hypoglycemia develops.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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