Drug interactions
Glecaprevir / pibrentasvir + Hydrochlorothiazide-olmesartan
Severity: Minor
Glecaprevir / pibrentasvir and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit hepatic uptake transporters OATP1B1 and OATP1B3, which can raise olmesartan plasma concentrations. This may enhance blood pressure lowering and adverse effects of olmesartan.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of OATP1B1/1B3-mediated hepatic uptake of olmesartan.
What to do
Monitor blood pressure and renal function during the hepatitis C treatment course. Reduce olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit hepatic uptake transporters OATP1B1 and OATP1B3, which can raise olmesartan plasma concentrations. This may enhance blood pressure lowering and adverse effects of olmesartan.
How serious is the interaction between Glecaprevir / pibrentasvir and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and renal function during the hepatitis C treatment course. Reduce olmesartan dose if hypotension occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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