Drug interactions
Glecaprevir / pibrentasvir + Hydrocortisone
Severity: Minor
Glecaprevir / pibrentasvir and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein, which may modestly increase hydrocortisone exposure. The effect is expected to be small and rarely clinically important.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of P-glycoprotein efflux by glecaprevir and pibrentasvir may increase hydrocortisone absorption and reduce its clearance.
What to do
No dose adjustment is usually needed. Be alert for signs of glucocorticoid excess if high or prolonged hydrocortisone doses are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Hydrocortisone?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein, which may modestly increase hydrocortisone exposure. The effect is expected to be small and rarely clinically important.
How serious is the interaction between Glecaprevir / pibrentasvir and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Be alert for signs of glucocorticoid excess if high or prolonged hydrocortisone doses are used.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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