Drug interactions
Glecaprevir / pibrentasvir + Idarubicin
Severity: Moderate
Glecaprevir / pibrentasvir and Idarubicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both components inhibit P-glycoprotein and may increase idarubicin exposure, raising the risk of toxicity. Data on this specific pair are lacking.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
P-gp inhibition by glecaprevir and pibrentasvir reduces idarubicin efflux.
What to do
Monitor blood counts and cardiac status during co-treatment. Reduce the idarubicin dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Idarubicin
- Adenovirus types 4 and 7 live + Idarubicin Contraindicated
- Belatacept + Idarubicin Major
- Cyclophosphamide + Idarubicin Major
- Deferiprone + Idarubicin Major
- Dengue vaccine + Idarubicin Major
- Etrasimod + Idarubicin Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Idarubicin?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Idarubicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both components inhibit P-glycoprotein and may increase idarubicin exposure, raising the risk of toxicity. Data on this specific pair are lacking.
How serious is the interaction between Glecaprevir / pibrentasvir and Idarubicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac status during co-treatment. Reduce the idarubicin dose if toxicity develops.
What other medicines interact with Idarubicin?
MediHelp also lists interactions of Idarubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclophosphamide. The full list is on the Idarubicin page.
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