Drug interactions
Glecaprevir / pibrentasvir + Isoniazid
Severity: Minor
Glecaprevir / pibrentasvir and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir is partly metabolized by CYP3A4, but isoniazid inhibition is weak and no relevant exposure change is expected. Both agents can affect the liver, which matters in patients with hepatitis C.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical weak CYP3A4 inhibition by isoniazid; additive hepatic risk.
What to do
No dose adjustment is needed. Monitor liver enzymes during combined treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Isoniazid
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Isoniazid?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir is partly metabolized by CYP3A4, but isoniazid inhibition is weak and no relevant exposure change is expected. Both agents can affect the liver, which matters in patients with hepatitis C.
How serious is the interaction between Glecaprevir / pibrentasvir and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor liver enzymes during combined treatment.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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