Drug interactions
Glecaprevir / pibrentasvir + Metformin-sitagliptin
Severity: Minor
Glecaprevir / pibrentasvir and Metformin-sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may modestly increase sitagliptin concentrations. Sitagliptin is well tolerated at higher exposure, so clinical significance is limited. Glucose control can also change as hepatitis C is treated.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-glycoprotein efflux increases sitagliptin absorption.
What to do
No dose adjustment is usually needed for sitagliptin. Monitor blood glucose during hepatitis C treatment, since improved glycemia may require dose reduction of antidiabetic drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-sitagliptin
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Metformin-sitagliptin?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Metformin-sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may modestly increase sitagliptin concentrations. Sitagliptin is well tolerated at higher exposure, so clinical significance is limited. Glucose control can also change as hepatitis C is treated.
How serious is the interaction between Glecaprevir / pibrentasvir and Metformin-sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed for sitagliptin. Monitor blood glucose during hepatitis C treatment, since improved glycemia may require dose reduction of antidiabetic drugs.
What other medicines interact with Metformin-sitagliptin?
MediHelp also lists interactions of Metformin-sitagliptin with, for example, Clozapine, Contrast media, Diatrizoate meglumine / diatrizoate. The full list is on the Metformin-sitagliptin page.
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