Drug interactions
Glecaprevir / pibrentasvir + Olmesartan
Severity: Moderate
Glecaprevir / pibrentasvir and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit hepatic uptake transporters, which may raise olmesartan plasma concentrations. Higher exposure could increase the risk of hypotension, hyperkalemia and renal effects.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3 hepatic uptake transport reduces olmesartan clearance.
What to do
Monitor blood pressure, potassium and renal function during the hepatitis C treatment course. Reduce the olmesartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Olmesartan?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit hepatic uptake transporters, which may raise olmesartan plasma concentrations. Higher exposure could increase the risk of hypotension, hyperkalemia and renal effects.
How serious is the interaction between Glecaprevir / pibrentasvir and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function during the hepatitis C treatment course. Reduce the olmesartan dose if hypotension occurs.
What other medicines interact with Olmesartan?
MediHelp also lists interactions of Olmesartan with, for example, Aliskiren, Sparsentan, Aldesleukin. The full list is on the Olmesartan page.
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