Drug interactions
Glecaprevir / pibrentasvir + Prazosin
Severity: Minor
Glecaprevir / pibrentasvir and Prazosin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may raise prazosin concentrations. This could enhance hypotension, but the clinical effect is unconfirmed.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-glycoprotein by glecaprevir/pibrentasvir may increase prazosin exposure.
What to do
Monitor blood pressure and orthostatic symptoms during the antiviral course. Reduce the prazosin dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Prazosin?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Prazosin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may raise prazosin concentrations. This could enhance hypotension, but the clinical effect is unconfirmed.
How serious is the interaction between Glecaprevir / pibrentasvir and Prazosin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms during the antiviral course. Reduce the prazosin dose if hypotension occurs.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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