Drug interactions
Glecaprevir / pibrentasvir + Propranolol
Severity: Minor
Glecaprevir / pibrentasvir and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir are P-gp substrates and inhibitors, but propranolol is not a meaningful inhibitor of this transporter. A clinically relevant rise in their levels from propranolol is unlikely.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak P-glycoprotein inhibition by propranolol; no established clinically significant effect.
What to do
No dose adjustment is needed. Monitor heart rate as usual in patients taking propranolol.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Propranolol?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir are P-gp substrates and inhibitors, but propranolol is not a meaningful inhibitor of this transporter. A clinically relevant rise in their levels from propranolol is unlikely.
How serious is the interaction between Glecaprevir / pibrentasvir and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor heart rate as usual in patients taking propranolol.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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