Drug interactions
Glecaprevir / pibrentasvir + Rifaximin
Severity: Minor
Glecaprevir / pibrentasvir and Rifaximin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-glycoprotein and may raise systemic rifaximin exposure. Given rifaximin's minimal absorption, effects are usually small.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition reducing rifaximin efflux.
What to do
No dose change is normally required. Be attentive to rifaximin adverse effects in severe hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Rifaximin?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Rifaximin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-glycoprotein and may raise systemic rifaximin exposure. Given rifaximin's minimal absorption, effects are usually small.
How serious is the interaction between Glecaprevir / pibrentasvir and Rifaximin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally required. Be attentive to rifaximin adverse effects in severe hepatic impairment.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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