Drug interactions
Glecaprevir / pibrentasvir + Telmisartan-amlodipine
Severity: Moderate
Glecaprevir / pibrentasvir and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit intestinal and hepatic transporters such as OATP1B1/1B3, P-gp and BCRP, and may raise telmisartan exposure. Higher telmisartan levels could increase hypotension, hyperkalemia or renal effects.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3 and efflux transporters by glecaprevir/pibrentasvir increases systemic exposure to telmisartan.
What to do
Monitor blood pressure, potassium and renal function during the hepatitis C treatment course. Reduce the telmisartan dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit intestinal and hepatic transporters such as OATP1B1/1B3, P-gp and BCRP, and may raise telmisartan exposure. Higher telmisartan levels could increase hypotension, hyperkalemia or renal effects.
How serious is the interaction between Glecaprevir / pibrentasvir and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function during the hepatitis C treatment course. Reduce the telmisartan dose if hypotension occurs.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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