Drug interactions
Glecaprevir / pibrentasvir + Telmisartan
Severity: Moderate
Glecaprevir / pibrentasvir and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit OATP1B1/3 and other transporters and may raise telmisartan exposure. Telmisartan is not expected to change antiviral exposure meaningfully, and the main concern is increased ARB effects such as hypotension or hyperkalemia.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of hepatic uptake transporters (OATP1B1/3) and possibly P-gp by glecaprevir/pibrentasvir increases telmisartan plasma concentrations.
What to do
Monitor blood pressure and potassium and renal function during the antiviral course. Reduce the telmisartan dose if hypotension or other adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Telmisartan?
MediHelp rates the interaction as moderate. Glecaprevir / pibrentasvir and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glecaprevir and pibrentasvir inhibit OATP1B1/3 and other transporters and may raise telmisartan exposure. Telmisartan is not expected to change antiviral exposure meaningfully, and the main concern is increased ARB effects such as hypotension or hyperkalemia.
How serious is the interaction between Glecaprevir / pibrentasvir and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and potassium and renal function during the antiviral course. Reduce the telmisartan dose if hypotension or other adverse effects occur.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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