Drug interactions
Glecaprevir / pibrentasvir + Tenofovir disoproxil
Severity: Minor
Glecaprevir / pibrentasvir and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glecaprevir and pibrentasvir inhibit P-gp and BCRP and can increase absorption of tenofovir disoproxil. Increases in tenofovir exposure have been small and generally not clinically significant.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal P-gp and BCRP increases tenofovir absorption.
What to do
No dose adjustment is needed. Monitor renal function as routinely recommended for tenofovir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glecaprevir and pibrentasvir inhibit P-gp and BCRP and can increase absorption of tenofovir disoproxil. Increases in tenofovir exposure have been small and generally not clinically significant.
How serious is the interaction between Glecaprevir / pibrentasvir and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor renal function as routinely recommended for tenofovir.
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