Drug interactions
Glecaprevir / pibrentasvir + Ulipristal
Severity: Minor
Glecaprevir / pibrentasvir and Ulipristal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal may inhibit P-glycoprotein and modestly increase glecaprevir and pibrentasvir exposure. A single emergency contraceptive dose is unlikely to cause significant harm.
What this interaction means in plain words
Glecaprevir / pibrentasvir and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-glycoprotein inhibition by ulipristal may reduce efflux of glecaprevir and pibrentasvir.
What to do
No routine adjustment is needed. Monitor for glecaprevir/pibrentasvir adverse effects such as headache and fatigue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Frequently asked questions
Can I take Glecaprevir / pibrentasvir with Ulipristal?
MediHelp rates the interaction as minor. Glecaprevir / pibrentasvir and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ulipristal may inhibit P-glycoprotein and modestly increase glecaprevir and pibrentasvir exposure. A single emergency contraceptive dose is unlikely to cause significant harm.
How serious is the interaction between Glecaprevir / pibrentasvir and Ulipristal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for glecaprevir/pibrentasvir adverse effects such as headache and fatigue.
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