Drug interactions
Glibenclamide + Gymnema
Severity: Moderate
Glibenclamide and Gymnema: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gymnema sylvestre has glucose-lowering activity and may add to the effect of glyburide, increasing the chance of hypoglycemia. Product content varies and the clinical data are limited.
What this interaction means in plain words
Glibenclamide and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypoglycemic effect, possibly through reduced intestinal glucose absorption and increased insulin secretion.
What to do
Monitor blood glucose closely if the patient uses gymnema, and reduce the glyburide dose if hypoglycemia occurs. Advise against starting herbal glucose-lowering products without review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Gymnema?
MediHelp rates the interaction as moderate. Glibenclamide and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gymnema sylvestre has glucose-lowering activity and may add to the effect of glyburide, increasing the chance of hypoglycemia. Product content varies and the clinical data are limited.
How serious is the interaction between Glibenclamide and Gymnema?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely if the patient uses gymnema, and reduce the glyburide dose if hypoglycemia occurs. Advise against starting herbal glucose-lowering products without review.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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