Drug interactions
Glibenclamide + Ibuprofen / famotidine
Severity: Minor
Glibenclamide and Ibuprofen / famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine raises gastric pH, which has little documented effect on glyburide absorption. Ibuprofen has a weak potential to enhance sulfonylurea effects. Overall the interaction is unlikely to be clinically important.
What this interaction means in plain words
Glibenclamide and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Higher gastric pH could alter glyburide dissolution, and NSAIDs may weakly displace sulfonylureas from protein binding; effects are small.
What to do
No routine adjustment is needed; monitor blood glucose if combined with other glucose-altering factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Ibuprofen / famotidine?
MediHelp rates the interaction as minor. Glibenclamide and Ibuprofen / famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine raises gastric pH, which has little documented effect on glyburide absorption. Ibuprofen has a weak potential to enhance sulfonylurea effects. Overall the interaction is unlikely to be clinically important.
How serious is the interaction between Glibenclamide and Ibuprofen / famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood glucose if combined with other glucose-altering factors.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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