Drug interactions
Glibenclamide + Insulin inhaled
Severity: Moderate
Glibenclamide and Insulin inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled insulin and sulfonylureas have additive glucose-lowering effects, raising the risk of hypoglycemia. Doses may need adjustment when either drug is started or stopped.
What this interaction means in plain words
Glibenclamide and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effects of insulin and a sulfonylurea.
What to do
Monitor blood glucose closely and reduce the glyburide or insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Insulin inhaled?
MediHelp rates the interaction as moderate. Glibenclamide and Insulin inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled insulin and sulfonylureas have additive glucose-lowering effects, raising the risk of hypoglycemia. Doses may need adjustment when either drug is started or stopped.
How serious is the interaction between Glibenclamide and Insulin inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the glyburide or insulin dose if hypoglycemia occurs.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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