Drug interactions
Glibenclamide + Insulin lispro
Severity: Moderate
Glibenclamide and Insulin lispro: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with glyburide increases the risk of hypoglycemia, which may be prolonged because glyburide has long-acting active metabolites. Risk is higher in elderly patients and those with renal impairment.
What this interaction means in plain words
Glibenclamide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Insulin lispro belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and sulfonylurea-stimulated endogenous insulin secretion.
What to do
Monitor glucose frequently and lower the glyburide or insulin dose if hypoglycemia occurs. Consider a shorter-acting agent in older patients or those with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin lispro
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Insulin lispro?
MediHelp rates the interaction as moderate. Glibenclamide and Insulin lispro can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with glyburide increases the risk of hypoglycemia, which may be prolonged because glyburide has long-acting active metabolites. Risk is higher in elderly patients and those with renal impairment.
How serious is the interaction between Glibenclamide and Insulin lispro?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose frequently and lower the glyburide or insulin dose if hypoglycemia occurs. Consider a shorter-acting agent in older patients or those with reduced renal function.
What other medicines interact with Insulin lispro?
MediHelp also lists interactions of Insulin lispro with, for example, Alogliptin-pioglitazone, Ethanol, Metreleptin. The full list is on the Insulin lispro page.
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