Drug interactions
Glibenclamide + Ketorolac intranasal
Severity: Minor
Glibenclamide and Ketorolac intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may occasionally enhance sulfonylurea effects, and ketorolac can impair renal function, which can prolong glyburide's active metabolites. The risk with short-term intranasal use is low but hypoglycemia is possible.
What this interaction means in plain words
Glibenclamide and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible protein-binding displacement and NSAID-related renal impairment reducing clearance of glyburide metabolites; not firmly established.
What to do
Monitor blood glucose and renal function during ketorolac use, keep treatment short, and avoid in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glibenclamide with Ketorolac intranasal?
MediHelp rates the interaction as minor. Glibenclamide and Ketorolac intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may occasionally enhance sulfonylurea effects, and ketorolac can impair renal function, which can prolong glyburide's active metabolites. The risk with short-term intranasal use is low but hypoglycemia is possible.
How serious is the interaction between Glibenclamide and Ketorolac intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function during ketorolac use, keep treatment short, and avoid in patients with renal impairment.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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