Drug interactions
Glibenclamide + Lonapegsomatropin
Severity: Moderate
Glibenclamide and Lonapegsomatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Growth hormone products can reduce insulin sensitivity and raise blood glucose, particularly at higher doses. This may counteract the glucose-lowering effect of glyburide and lead to loss of glycemic control in people with diabetes.
What this interaction means in plain words
Glibenclamide and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glibenclamide belongs to Endocrine; Lonapegsomatropin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through growth hormone-induced insulin resistance.
What to do
Monitor blood glucose and HbA1c when starting or adjusting lonapegsomatropin. Increase glyburide or other antidiabetic therapy if hyperglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Other interactions of Lonapegsomatropin
Frequently asked questions
Can I take Glibenclamide with Lonapegsomatropin?
MediHelp rates the interaction as moderate. Glibenclamide and Lonapegsomatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Growth hormone products can reduce insulin sensitivity and raise blood glucose, particularly at higher doses. This may counteract the glucose-lowering effect of glyburide and lead to loss of glycemic control in people with diabetes.
How serious is the interaction between Glibenclamide and Lonapegsomatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or adjusting lonapegsomatropin. Increase glyburide or other antidiabetic therapy if hyperglycemia develops.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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